Unable to activate Windows Store app (Visual Studio 2015, Windows 10 Version 1511)

Question

Today I updated my Windows 10 PC to Threshold 2. The update went fine apart from Visual Studio refusing to run any of my Universal Windows 10 projects (including new ones).

When I try run an app I get this message:

Unable to activate Windows Store app '{App}'. The {App name}.exe
process started, but the activation request failed with error 'The app
didn't start'.

I have tried everything:

• Repairing / Uninstalling then Installing Visual Studio
• Cleaned the Solution
• Deleted the 'bin' and 'obj' folders
• Checked for SDK/Visual Studio updates
• Checked if there was an app.json (there wasn't)
• Updated Nuget Packages
• Tried different projects (including new blank ones - same errors)
• Resetting Windows (from settings screen)

Extra Info

• Visual Studio is installed on a second (storage) drive, as my main drive is a small SSD.
• Everything worked fine before I upgraded.

Answer 1

I managed to fix the problem by checking the box "Compile with .NET Native tool chain" under project's "Properties --> Build" -tab.

similarly in official troubleshooting page this Native and cleanup tips are mentioned

Answer 2

Turns out that my Visual Studio projects must be on my C:/ drive and not a storage drive. All fixed.