I've successfully setup one Django application using virtualenv on Ubuntu and Apache 2, using the WSGIPythonHome directive pointing to my virtualenv location.  Now I am in need to create a separate Django application, that is going to run on Apache on a different port on the same Ubuntu server.  I am wondering if there's a way to have Apache run multiple WSGIPythonHome instances?  Currently with WSGIPythonHome being set to one virtualenv root, there's a problem with imports on the second Django app…
The best way to do this, I've discovered about a year ago, is to use WSGI as a daemon and set the python path in the daemon directive. Example is below
<VirtualHost *:80>
    ServerName yourhost.com
    <Directory />
      Order deny,allow
      #Require all granted
    </Directory>
    #Alias /static /opt/yourhost/static
    WSGIScriptAlias / /opt/yourhost/wsgi.py
    WSGIApplicationGroup %{GLOBAL}
    WSGIDaemonProcess yourhost.com python-path=/opt/yourhost:/opt/yourhost/venv/lib/python2.7/site-packages processes=2 threads=15 display-name=%{GROUP}
    WSGIProcessGroup  yourhost.com
</VirtualHost>
WSGISocketPrefix /var/run/wsgi
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