<Grid x:Name="LayoutRoot">
    <ComboBox x:Name="com_ColorItems" Height="41" Margin="198,114,264,0" VerticalAlignment="Top" FontSize="13.333" FontWeight="Bold" Foreground="#FF3F7E24"/>
</Grid>
With above code I colored all items in the combobox green.
private void Window_Loaded(object sender, RoutedEventArgs e)
{
        for (int i = 0; i < 5; i++)
        {
            com_ColorItems.Items.Add(i);
        }
}
With above code I have filled five items into combobox. Now I like to change the color of the 3rd item (3) to "red" in code behind dynamically. How can I do that?
Instead of adding the actual value of i in the combobox, add a ComboBoxItem instead:
private void Window_Loaded(object sender, RoutedEventArgs e)
    {
        for (int i = 0; i < 5; i++)
        {
            ComboBoxItem item = new ComboBoxItem();
            if (i == 2) item.Foreground = Brushes.Blue;
            else item.Foreground = Brushes.Pink;
            item.Content = i.ToString();
            com_ColorItems.Items.Add(item);
        }
    }
If you want to modify the ComboBoxItem created with this method later, this is how you can do it:
var item = com_ColorItems.Items[2] as ComboBoxItem; // Convert from Object
if (item != null)                                   // Conversion succeeded 
{
    item.Foreground = Brushes.Tomato;
}
                        First, try to bind your Source and avoid the directly access through code behind. And than you can use an Converter in your ItemSource Binding.
e.g.
ItemSource={Binding MyComboboxItems, Converter={StaticResource MyConverter}}
and in your Converter find you the 3rd Item and give them a different ForegroundColor
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