Safely move Microsoft SDKs folder

I have a folder on my hard drive, C:\Program Files\Microsoft SDKs, and I was wondering if it is safe to move it to an external drive. Does Visual Studio or any other tool depend on this particular folder?

There are quite a number of entries in the registry (at least in my registry) that point to that location, so it seems something would work in a less than optimal fashion. At a minimum, it would make the uninstaller a bit confused. It is probably safe to simply rename the directory temporarily and try your builds to see if they still work. Ultimately, though, it seems it would be cleanest to run the installation again to actually remove it and then install to a new location.