I've noticed that in different versions of Internet Explorer the onchange event is not captured when the value of an input is altered by a js function, behavior that does not occur with other browsers such as Mozilla or Chrome.
Investigating a little I found that the correct operation of onchange in IE is not guaranteed when the value is altered by js:
onchange not fired when autocomplete is on
Example (test on IE):
function onchangeRequest(){
  console.log('onchange fired');
}
function changeValue (input){
  input.value +=  "hello"
}
<h4> focus lost doesnt invoke onchangeRequest() </h4>
<input id="valueInput"  onkeyup="changeValue(this);" onchange="onchangeRequest();" />
<h4> focus lost invokes onchangeRequest() </h4>
<input id="valueInput" onchange="onchangeRequest();" />
I have not found a convincing explanation of the reasons why IE does not solve those situations correctly. Is this a "known bug" which we have to deal with? Is there any official reference where it is stated that IE does not guarantee the correct behavior of onchange event?
I have found that for many years Microsoft followed a strategy whereby it didnt follow the W3C standards in its browser, but the behavior is correct according to IE's own specification:
The onchange event does not fire when the selected option of the select object is changed programmatically.
Reference: MSDN - onchange event
A possible workaround to solve this problem and make your solution cross browser would be:
onfocus: save the input value on a expando property
onblur: call a js function that compares the old value with the current value. In my real life scenario i need to fire an ajax action just when the input value changed, so using onblur event without comparing changes would result in a lot of unnecessary calls to the backend. 
Here is an example:
function onchangeRequest(input){
  if(input.value != input.oldValue){
      console.log('value changed: do ajax request');
  }else{
      console.log('value didnt change');
  }
}
function changeValue (input){
     input.value +=  "add"
 }
<input id="valueInput" onkeyup="changeValue(this);" onfocus="this.oldValue = this.value;" onblur="onchangeRequest(this);" />
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