Mac + Uno + avrdude: stk500_recv(): programmer is not responding

Question

I'm trying to upload .hex file to Arduino. I don't have any problems with uploading code through an IDE (like blink example or any other). The port and board are correct.

So, the problem appears when I try to upload

avrdude -pm328p -carduino -P/dev/tty.usbmodemfd121 -b57600 -D -Uflash:w:grbl_v0_8c_atmega328p_16mhz_9600.hex -v -v -v -v

avrdude: Version 6.1, compiled on Mar 23 2014 at 04:42:55
     Copyright (c) 2000-2005 Brian Dean, http://www.bdmicro.com/
     Copyright (c) 2007-2014 Joerg Wunsch

     System wide configuration file is "/usr/local/Cellar/avrdude/6.1/etc/avrdude.conf"
     User configuration file is "/Users/Mikhail/.avrduderc"
     User configuration file does not exist or is not a regular file, skipping

     Using Port                    : /dev/tty.usbmodemfd121
     Using Programmer              : arduino
     Overriding Baud Rate          : 57600
avrdude: Send: 0 [30]   [20] 
avrdude: Send: 0 [30]   [20] 
avrdude: Send: 0 [30]   [20] 
avrdude: ser_recv(): programmer is not responding
avrdude: stk500_recv(): programmer is not responding
avrdude: stk500_getsync() attempt 1 of 10: not in sync: resp=0x00

What I tried:

• I have 4 Uno's at the table (original + free versions), the same issue.
• I have installed newest drivers from here, tried with and without them.
• tried with avrdude which comes with Arduino IDE (1.0.5 and nightly builds) and newest avrdude v.6.1 brew install avrdude
• different baud rates down to 9600
• tried to press reset after bytes are sent like suggested here

Answer 1

One more reason to fail : wrong bootloader

Recently purchased an Arduino nano and when tried to upload Blink for testing purposes it failed. Because the board was manufactured previously to Jan 2018 just selecting Processor > "ATmega328P (Old Bootloader)" solved the problem (https://www.arduino.cc/en/Guide/ArduinoNano#toc4)

Answer 2

What fixed it for me was:

• Disconnect the USB cable from the Arduino
• Try to upload your program
• This will fail and the Arduino app will ask you which USB port to use.
• I did this twice
• Then plug in the USB cable to the Arduino
• Upload you program... succes!

Note: Shortly before I installed the drivers mentioned by Mikhail.

Setup: Mac OS 10.9.5, Arduino.app 1.0.6, Arduino Duemilanove