On Windows, it's common practice to create a named mutex and use the presence of that to determine that an instance of a given app is already running. This has its drawbacks, but mostly works.
I can think of a ways to do this on the Mac:
Is there something built into Cocoa/Carbon that's easier than the options above? If not, which of the three are most used on the mac? I would assume 2 or 3...
To elaborate further on using NSWorkspace. Try using launchedApplications in NSWorkspace. This returns an NSArray containing a dictionary for each launched application. You can loop through the array to see if the app you are looking for is already running. I would advise that you use the value with the key NSApplicationBundleIdentifier which will have a value like "com.mycompany.myapp" rather than looking for the name. If you need to find the bundle identifier for an app you can look at its info.plist file in the app package.
Macs do not have instances in the same way as Windows does. Generally speaking you want the application running twice you physically need to copy the binary and then double click on the copied version as well.
If you need two instances of an application running then you are not thinking like a Mac user :).
Edit: This is technically not true. Check the comments.
Mapping process management among disparate operating systems doesn't work. Or doesn't work well. By default and without particular effort, you get one copy and only one copy of the application.
Here's a previous similar question that goes a step further than this current question, and with some replies that discuss interlocking when there are multiple copies of an image, or multiple applications that need coordination.
How to detect whether an OS X application is already launched
For an introduction to the run-time context and particularly around Mac OS X daemons and agents (and for those cases when you do need to have multiple copies of an executable running, as a pool or such and akin to Apache), see:
http://developer.apple.com/technotes/tn2005/tn2083.html
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