I have various csv files and I import them as a DataFrame. The problem is that many files use different symbols for missing values. Some use nan, others NaN, ND, None, missing etc. or just live the entry empty. Is there a way to replace all these values with a np.nan? In other words, any non-numeric value in the dataframe becomes np.nan. Thank you for the help.
# Create a custom list of values I want to cast to NaN, and explicitly 
#   define the data types of columns:
na_values = ['None', '(S)', 'S']
last_names = pd.read_csv('names_2010_census.csv', dtype={'pctapi': np.float64}, na_values=na_values)
I believe best practices when working with messy data is to:
This is quite easy to do.
Pandas read_csv has a list of values that it looks for and automatically casts to NaN when parsing the data (see the documentation of read_csv for the list). You can extend this list using the na_values parameter, and you can tell pandas how to cast particular columns using the dtypes parameter.
In the example above, pctapi is the name of a column that was casting to object type instead of float64, due to NaN values. So, I force pandas to cast to float64 and provide the read_csv function with a list of values to cast to NaN.
Since data science is often completely about process, I thought I describe the steps I use to create an na_values list and debug this issue with a dataset.

In the example above, Pandas was right on about half the columns. However, I expected all columns listed below the 'count' field to be of type float64. We'll need to fix this.
# note: the dtypes dictionary specifying types. pandas will attempt to infer
#   the type of any column name that's not listed
last_names = pd.read_csv('names_2010_census.csv', dtype={'pctwhite': np.float64})
Here's the error message I receive when running the code above:

From the error message, I can see that pandas was unable to cast the value of (S). I add this to my list of na_values:
# note the new na_values argument provided to read_csv
last_names = pd.read_csv('names_2010_census.csv', dtype={'pctwhite': np.float64}, na_values=['(S)'])
Finally, I repeat steps 2 & 3 until I have a comprehensive list of dtype mappings and na_values.
If you're working on a hobbyist project this method may be more than you need, you may want to use u/instant's answer instead. However, if you're working in production systems or on a team, it's well worth the 10 minutes it takes to correctly cast your columns.
I found what I think is a relatively elegant but also robust method:
def isnumber(x):
    try:
        float(x)
        return True
    except:
        return False
df[df.applymap(isnumber)]
In case it's not clear: You define a function that returns True only if whatever input you have can be converted to a float. You then filter df with that boolean dataframe, which automatically assigns NaN to the cells you didn't filter for.
Another solution I tried was to define isnumber as
import number
def isnumber(x):
    return isinstance(x, number.Number)
but what I liked less about that approach is that you can accidentally have a number as a string, so you would mistakenly filter those out. This is also a sneaky error, seeing that the dataframe displays the string "99" the same as the number 99.
EDIT:
In your case you probably still need to df = df.applymap(float) after filtering, for the reason that float works on all different capitalizations of 'nan', but until you explicitely convert them they will still be considered strings in the dataframe.
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