How do I make an area unclickable with CSS?

Question

Let's say if I have wrapper div which includes some links and images, is there any way I can deactivate it at once with CSS only?

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After review of answers:
I dropped the idea that can make it with CSS only. jQuery blockUI plug in works like charm.

Answer 1

There is a CSS rule for that, but it's not widely used because of old browsers support

pointer-events: none;