I make some Ajax calls from inside a javascript object.:
myObject.prototye = {
  ajax: function() {
    this.foo = 1;
    var req = new XMLHttpRequest();
    req.open('GET', url, true);
    req.onreadystatechange = function (aEvt) {  
      if (req.readyState == 4) {  
        if(req.status == 200)  {
          alert(this.foo); // reference to this is lost
        }
      }
  }
};
Inside the onreadystatechange function, this does not refer to the main object anymore, so I don't have access to this.foo. Ho can I keep the reference to the main object inside XMLHttpRequest events?
The most simple approach is usually to store the value of this on a local variable:
myObject.prototype = {
  ajax: function (url) { // (url argument missing ?)
    var instance = this; // <-- store reference to the `this` value
    this.foo = 1;
    var req = new XMLHttpRequest();
    req.open('GET', url, true);
    req.onreadystatechange = function (aEvt) {  
      if (req.readyState == 4) {  
        if (req.status == 200)  {
          alert(instance.foo); // <-- use the reference
        }
      }
    };
  }
};
I suspect also that your myObject identifier is really a constructor function (you are assigning a prototype property).
If that's the case don't forget to include the right constructor property (since you are replacing the entire prototype), which is simply a reference back to the constructor.
Maybe off-topic to this issue but recommended to read:
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