I am calling an API in my Index Controller like this and everything works fine, only if I have Fiddler open.
public ActionResult Index()
{
    Base model = null;
    var client = new HttpClient();
    var task =
        client.GetAsync(
        "http://example.api.com/users/john/profile")
        .ContinueWith((taskwithresponse) =>
        {
            var response = taskwithresponse.Result;
            var readtask = response.Content.ReadAsAsync<Base>();
            readtask.Wait();
            model = readtask.Result;
        });
    task.Wait();
    return View(model);
}
If I close Fiddler I get following error:
No connection could be made because the target machine actively refused it 127.0.0.1:8888
Is there some configuration I have to include, so that calling an API works, even if I don't have Fiddler open.
Check web.config for any proxy configuration, and also check whether you have configured a system default proxy which .net might use. You can add this to your web.config to disable proxy configuration:
    <system.net>
      <!-- set enabled to true to use the system default proxy -->
      <defaultProxy enabled="false" />
    </system.net>
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