I've read that it's unwise to install SQL Server and IIS on the same machine, but I haven't seen any evidence for that. Has anybody tried this, and if so, what were the results? At what point is it necessary to separate them? Is any tuning necessary? I'm concerned specifically with IIS7 and SQL Server 2008.
If somebody can provide numbers showing when it makes more sense to go to two machines, that would be most helpful.
It is unwise to run SQL Server with any other product, including another instance of SQL Server. The reason for this recommendation is the nature of of how SQL Server uses the OS resources. SQL Server runs on an user mode memory management and processor scheduling infrastructure called SQLOS. SQL Server is designed to run at peak performance and assumes that is the only server on the OS. As such the SQL OS reserves all RAM on the machine for SQL process and creates a scheduler for each CPU core and allocates tasks for all schedulers to run, utilizing all CPU it can get, when it needs it. Because SQL reserves all memory, other processes that need memory will cause SQL to see memory pressure, and the response to memory pressure will evict pages from buffer pool and compiled plans from the plan cache. And since SQL is the only server that actually leverages the memory notification API (there are rumors that the next Exchange will too), SQL is the only process that actually shrinks to give room to other processes (like leaky buggy ASP pools). This behavior is also explained in BOL: Dynamic Memory Management.
A similar pattern happens with CPU scheduling where other processes steal CPU time from the SQL schedulers. On high end systems and on Opteron machines things get worse because SQL uses NUMA locality to full advantage, but no other processes are usually not aware of NUMA and, as much as the OS can try to preserve locality of allocations, they end up allocating all over the physical RAM and reduce the overall throughput of the system as the CPUs are idling on waiting for cross-numa boundary page access. There are other things to consider too like TLB and L2 miss increase due to other processes taking up CPU cycles.
So to sum up, you can run other servers with SQL Server, but is not recommended. If you must, then make sure you isolate the two server to your best ability. Use CPU affinity masks for both SQL and IIS/ASP to isolate the two on separate cores, configure SQL to reserve less RAM so that it leaves free memory for IIS/ASP, configure your app pools to recycle aggressively to prevent application pool growth.
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