Right now I'm developing the prototype of a web application that aggregates large number of text entries from a large number of users. This data must be frequently displayed back and often updated. At the moment I store the content inside a MySQL database and use NHibernate ORM layer to interact with the DB. I've got a table defined for users, roles, submissions, tags, notifications and etc. I like this solution because it works well and my code looks nice and sane, but I'm also worried about how MySQL will perform once the size of our database reaches a significant number. I feel that it may struggle performing join operations fast enough.
This has made me think about non-relational database system such as MongoDB, CouchDB, Cassandra or Hadoop. Unfortunately I have no experience with either. I've read some good reviews on MongoDB and it looks interesting. I'm happy to spend the time and learn if one turns out to be the way to go. I'd much appreciate any one offering points or issues to consider when going with none relational dbms?
NoSQL DB proves the best for such applications as these databases can store a vast amount of data without any limitations concerning data type or structure. Information can be stored in multiple formats as per business requirements. Such flexibility proves to be a life-saver for startups.
The other answers here have focused mainly on the technical aspects, but I think there are important points to be made that focus on the startup company aspect of things:
Basically, don't spend your time ( == money) worrying about which db to use, as MySQL can handle a lot of data, is well proven and well supported.
Going back to the technical side of things... Something that will have a far greater impact on the speed of your app than choice of db, is how efficiently data can be cached. An effective cache can have dramatic effects on reducing db load and speeding up the general responsivness of an app. I would spend your time investigating caching solutions and making sure you are developing your app in such a way that it can make the best use of those solutions.
FYI, my caching solution of choice is memcached.
So far no one has mentioned PostgreSQL as alternative to MySQL on the relational side. Be aware that MySQL libs are pure GPL, not LGPL. That might force you to release your code if you link to them, although maybe someone with more legal experience could tell you better the implications. On the other side, linking to a MySQL library is not the same that just connecting to the server and issue commands, you can do that with closed source.
PostreSQL is usually the best free replacement of Oracle and the BSD license should be more business friendly.
Since you prefer a non relational database, consider that the transition will be more dramatic. If you ever need to customize your database, you should also consider the license type factor.
There are three things that really have a deep impact on which one is your best database choice and you do not mention:
However most people will go for a non relational database just because they do not like learning SQL
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