Here code to update mail, department, title and mobile to null or empty value of AD user.
            var adSearch = new DirectorySearcher(ConnectHelper.ContxEntry);
            adSearch.Filter = "samAccountName=" + "....";
            var result = adSearch.FindOne();
            if (result != null)
            {
                DirectoryEntry user = result.GetDirectoryEntry();
                user.Properties["mail"].Value = null;
                user.Properties["Department"].Value = null;
                user.Properties["Title"].Value = null;
                user.Properties["mobile"].Value = null;
                user.CommitChanges();
            }
Error: "The attribute syntax specified to the directory service is invalid."
How can i set Value of some properties to null or empty???
Try using :
user.Properties["mail"].Clear() 
instead of :
user.Properties["mail"].Value = null;
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