"Unable to step. Process is not synchronized" error in VS2010 after upgrading .NET Framework

Question

I had Visual Studio 2010 installed on my Windows 7 desktop, that I was using primarily to debug ASP.NET solutions. Everything was working great, until one of the Windows updates installed a new version of the .NET Framework. Now I get the following message when I try to place a breakpoint and then do a "debugger step" in my C# code:

To make matters worse, it doesn't happen all the time. I tried to find any pattern, but the best way I can describe it is sporadic.

Any idea how to fix this?

Answer 1

I just got this in Visual Studio 2015. I was debugging on a separate thread, hit the breakpoint but could not continue. A reboot did not fix it.

I deleted all of my breakpoints, reset the two that I actually wanted and it works!