Runtime is not ready for debugging

Question

I'm on macOS Sierra using react native 0.42.3:

I start my app using react-native run-ios, then press Cmd-D and I select "Debug JS Remotely". After that, a new Chrome Tab is opened, and by switching into the dev tools I see my console with every outputs so far.

The problem is: When I reload my app, while the debugger is open, it crashes with the infamous red screen saying "Runtime is not ready for debugging".

I found a lot of posts about debugging with react native, but nothing seems to address the problem when you try to reload it.

Answer 1

These solutions both work:

1. On simulator: Hardware -> Erase All Content and Settings
2. On device: Delete the app from the device and reinstalling it

(Update credit to @Form and @John)