In a given numpy array X:
X = array([1,2,3,4,5,6,7,8,9,10])
I would like to replace indices (2, 3) and (7, 8) with a single element -1 respectively, like:
X = array([1,2,-1,5,6,7,-1,10])
In other words, I replaced values at indices (2, 3) and (7,8) of the original array with a singular value. 
Question is: Is there a numpy-ish way (i.e. without for loops and usage of python lists) around it? Thanks.
Note: This is NOT equivalent of replacing a single element in-place with another. Its about replacing multiple values with a "singular" value. Thanks.
A solution using numpy.delete, similar to @pault, but more efficient as it uses pure numpy indexing.  However, because of this efficient indexing, it means that you cannot pass jagged arrays as indices
Setup
a = np.array([1,2,3,4,5,6,7,8,9,10])
idx = np.stack([[2, 3], [7, 8]])
a[idx] = -1
np.delete(a, idx[:, 1:])
array([ 1,  2, -1,  5,  6,  7, -1, 10])
                        I'm not sure if this can be done in one step, but here's a way using np.delete:
import numpy as np
from operator import itemgetter
X = np.array(range(1,11))
to_replace = [[2,3], [7,8]]
X[list(map(itemgetter(0), to_replace))] = -1
X = np.delete(X, list(map(lambda x: x[1:], to_replace)))
print(X)
#[ 1  2 -1  5  6  7 -1 10]
First we replace the first element of each pair with -1. Then we delete the remaining elements.
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