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Remove substring matching pattern both in the beginning and the end of the variable

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As the title says, I'm looking for a way to remove a defined pattern both at the beginning of a variable and at the end. I know I have to use # and % but I don't know the correct syntax.

In this case, I want to remove http:// at the beginning, and /score/ at the end of the variable $line which is read from file.txt.