I had Gridview bind sqldatasource and I had logins which see gridview and I made roles for these logins som of them cannot see all gridview column so how can I make some columns read only .?
code public void CheckLoginAuthorty() {
    using (SqlConnection Con = Connection.GetConnection())
    {
        SqlCommand com = new SqlCommand("CheackLoginInRole", Con);
        com.CommandType = CommandType.StoredProcedure;
        com.Parameters.Add(Parameter.NewNVarChar("@Login", Session.Contents["Username"].ToString()));
        object O = com.ExecuteScalar();
        if (O != null)
        {
            string S = O.ToString();
            if (IsInRole("AR-Translator", O.ToString()))
            {
            ///////// Grideview code/////////////////   
            }
            else if (IsInRole("EN-Translator", O.ToString()))
            {
       /////////Grideview code/////////////////   
            }
        }
    }
}
                EDIT:
All you need to do is set the ReadOnly property to true
e.g.
WinForms DataGridView
dataGridView1.Columns["ColumnName"].ReadOnly = true;
WebForms GridView
((BoundField)gridView1.Columns[columnIndex]).ReadOnly = true;
                         DataGridViewColumn column;
 column.ReadOnly = true;
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