What is the most efficient way to concatenate two lists list_a and list_b when:  
list_b items have to be placed before list_a itemslist_a I have 4 possibilities in mind:
# 1 list_a = list_b + list_a  # 2 for item in list_b:     list_a.insert(0, item)  # 3 for item in self.list_a:     list_b.append(item) list_a = list_b  # 4 list_a[0:0] = list_b   Thanks!
Yes: list1 + list2 . This gives a new list that is the concatenation of list1 and list2 .
You can concatenate multiple lists into one list by using the * operator. For Example, [*list1, *list2] – concatenates the items in list1 and list2 and creates a new resultant list object.
1. Concatenation operator (+) for List Concatenation. The '+' operator can be used to concatenate two lists. It appends one list at the end of the other list and results in a new list as output.
To summarize: the difference between the + method and the += and extend() methods is that the former creates a new list and the latter modify an existing list object in-place.
Here's a graph of how the timings used in the answer of BigYellowCactus develop as the length of the lists increase. The vertical axis is the time required to initialize both lists and insert one in front of the other, in usec. The horizontal axis is the number of items in the lists.

t1:
list_a = list_b + list_a  t2:
for item in list_b:     list_a.insert(0, item)  t3:
for item in list_a:     list_b.append(item) list_a = list_b  t4:
list_a[0:0] = list_b 
                        Given that
list_a = list_b + list_a   works for your purposes, it follows that you don't actually need the list_a object itself to store all the data in list_a - you just need it called list_a (ie, you don't have, or don't care about, any other variables you have floating around that might refer to that same list). 
If you also happen not to care about it being exactly a list, but only about it being iterable, then you can use itertools.chain:
list_a = itertools.chain(list_b, list_a)   If you do care about some list things, you could construct a similar type of thing to chain that behaves like a list - something like:
class ListChain(list):     def __init__(self, *lists):         self._lists = lists      def __iter__(self):         return itertools.chain.from_iterable(self._lists)      def __len__(self):         return sum(len(l) for l in self._lists)      def append(self, item):         self._lists[-1].append(item)      def extend(self, iterable):         self._lists.append(list(iterable))      def __getitem__(self, item):        for l in self._lists:            if item < len(l):               return l[item]            item -= len(l)        else:           raise IndexError   etc. This would take a lot of effort (possibly more than its worth) for this to work in all cases - eg, handling slices and negative indexes comes to mind. But for very simple cases, this approach can avoid a lot of copying list contents around.
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