I have the "full" 3.9 MB Tailwind CSS file and successfully applied PurgeCSS to reduce it to 9 kB. But it also purged all responsive classes like md:px-6, they don't show up in my purged version.
Note: this question is for using the command line interface (CLI)
This is what I did:
purgecss --css ~/Desktop/Projects/Flask/Project1/build/static/css/main.css --content ~/Desktop/Projects/Flask//Project1/build/**/*.html --output ~/Desktop/Projects/Flask/Project2/static/css/main.css
I chose to create the output file in a different folder (Project2) so that I could check on the input vs output.
One thing I tried is to add  --safelist [/md/], but didn't help. In fact the safelist didn't seem to be used at all...
(I use CLI since it is part of a bigger Python Flask project)
PurgeCSS relies on extractors to get the list of selectors used in a file. It provides a default extractor that is working fine with a wide variety of file types, but it can be limited and does not fit every CSS framework out there.
The default extractor considers every word of a file as a selector but it doesn't consider special characters like the colon (:) which is heavily used in Tailwind CSS.
So, by default, PurgeCSS removes responsive (md:px-6), hover (hover:bg-gray-500), etc. classes. To avoid this, Tailwind has its own extractor. You could use this (or your very own) extractor but the PurgeCSS CLI has limited options and it's missing a defaultExtractor option.
Luckily, it accepts a config file option, so if you create your own purgecss.config.js file and add a default extractor in there, it will preserve these classes too. You can also add your other options to this file.
I used to use this extractor which will work with Tailwind's class names (e.g. bg-red-500, dark:bg-red-500, px-2.5, .max-w-[800px], bg-[#FFFFFF])
(content) => content.match(/[\w\-:.\/\[#%\]]+(?<!:)/g) || []
Your config file will look like this:
// purgecss.config.js
module.exports = {
  content: ['build/**/*.html'],
  css: ['build/static/css/main.css'],
  defaultExtractor: (content) => content.match(/[\w-/:]+(?<!:)/g) || [],
  output: 'static/css/main.css',
};
And you can use the following command to run PurgeCSS with the above config:
purgecss --config ./purgecss.config.js
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