I'm getting 403 – Forbidden: Access is denied on IIS v10 when trying to run ashx files.
I'm using classic application pool with identity Local System
Can you please help?
I would suggest you check the IIS logs, check the FRT logs, and Check the detailed error message. You could go to IIS > Error pages feature > Edit Features Settings... in Actions pane

Then, select Detailed errors option and click OK (Refer screenshot):

For testing purposes, try to give full permission to the site folder.
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