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In the past, the .NET framework has been independent from IIS versions, and have worked with IIS 6+.
Will IIS 6 be supported for .NET 4.5?
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NET 4.5. 1 cannot be installed on Windows 10, only 4.6 and later. So if your application is incompatible with . NET 4.6 and later you will need to update your application.
You can install . NET 4.5 in Windows 7 and Windows Vista, yes!
IIS 6 is part of Windows Server 2003 (and technically XP 64-bit).
The .NET Framework 4.5 System Requirements indicate that Server 2003, thus IIS 6, is not supported.
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