After upgrading to Windows 10, I am receiving the ERR_SPDY_INADEQUATE_TRANSPORT_SECURITY in Google Chrome (Firefox 39 just doesn't load the page) when I attempt to access my machine over HTTPS. I have a GoDaddy signed certificate for my computer.
I've attempted disabling most of my encryption ciphers per https://http2.github.io/http2-spec/#BadCipherSuites.
I've gone so far that I've disabled ciphers that are keeping me from RDPing to my desktop...and it still gives me an error!
Any guidance is appreciated.
Apparently you are not the only one having this issue: Disabling HTTP/2 / SPDY in HTTP.SYS and IIS in Windows 10
According to the error message this is a SPDY issue, so the certificate and the cipher suites are not the cause.
SPDY is a protocol allowing multiplexing HTTPS requests but it will be replaced by HTTP/2. As a temporary fix, you can apparently disable its support in you browser/registry/server.
I ran into this same issue after my win 10 dev machine got updated twice recently (the updates took around 35-40 minutes to deploy each time) and after this i was not able to run my Visual studio 2015 web applications over Https on Chrome but was able to run on IE
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