I read through the main answers on usage of slots and it has given me an idea of how and where to use __slots__ . 
Now, I am porting a code from Python 2 to Python 3 which is similar to as following:
class B(object):
    __slots__ = ('_fields')
    _fields = set()
But this is giving error Python 3 while working fine on Python 2:
ValueError: '_fields' in __slots__ conflicts with class variable. 
I change the code to
class B(object):
    __slots__ = ('_fields')
    def __init__(self):
        _fields = set()
and it works fine. My query is, is it even the correct change ?
As i got from original code, I guess it is saying that don't use __dict__ for saving memory or faster access or whatever reason but at the same time is also trying to specify the type of attribute _field as set(). Can the change above be the right way to say it or it can have some side effects.
Further Experiments: I experimented further with following variants (on Python 3):
import pdb
class A(object):
    a = set()
'''
class B(object):
    __slots__ = ('a')
    a = set()
'''
class C(object):
    __slots__ = ('a')
    def __init__(self):
        a = set()
class D(object):
    def __init__(self):
        __slots__ = ('a')
        a = set()
if __name__ == '__main__':
    #pdb.set_trace()
    x = A(); print(dir(x))
    #y = B()
    z = C(); print(dir(z))
    z1 = D(); print(dir(z1))
and it gave following output.
['__class__', '__delattr__', '__dict__', '__dir__', '__doc__', '__eq__', '__format__', '__ge__', '__getattribute__', '__gt__', '__hash__', '__init__', '__le__', '__lt__', '__module__', '__ne__', '__new__', '__reduce__', '__reduce_ex__', '__repr__', '__setattr__', '__sizeof__', '__str__', '__subclasshook__', '__weakref__', 'a']
['__class__', '__delattr__', '__dir__', '__doc__', '__eq__', '__format__', '__ge__', '__getattribute__', '__gt__', '__hash__', '__init__', '__le__', '__lt__', '__module__', '__ne__', '__new__', '__reduce__', '__reduce_ex__', '__repr__', '__setattr__', '__sizeof__', '__slots__', '__str__', '__subclasshook__', 'a']
['__class__', '__delattr__', '__dict__', '__dir__', '__doc__', '__eq__', '__format__', '__ge__', '__getattribute__', '__gt__', '__hash__', '__init__', '__le__', '__lt__', '__module__', '__ne__', '__new__', '__reduce__', '__reduce_ex__', '__repr__', '__setattr__', '__sizeof__', '__str__', '__subclasshook__', '__weakref__']
We can see that only C object shows correct footprint i.e. no __dict__ and only __slots__ . Isn't it what ideally we would want ? Any explanation on __weakref__ would also be helpful.
Also on Python 2, both B and C object show same footprint. Based on that should C be the right way to put it as it is compiling on both Python 2 and 3 as well.
But this is giving error Python 3 while working fine on Python 2:
ValueError: '_fields' in __slots__ conflicts with class variable.
While you didn't get an error in Python2 at class creation/compile time like in Py3k, if you try to actually set the value of _fields, you get AttributeError: 'C' object attribute '_fields' is read-only:
>>> class C(object):
...   __slots__ = ('_fields')
...   _fields = set()
...
>>>
>>> c = C()
>>> c._fields
set([])
>>> c._fields = 'foo'
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
AttributeError: 'C' object attribute '_fields' is read-only
>>>
Also, see the fourth note in the slots documentation:
__slots__are implemented at the class level by creating descriptors (Implementing Descriptors) for each variable name. As a result, class attributes cannot be used to set default values for instance variables defined by__slots__; otherwise, the class attribute would overwrite the descriptor assignment.
Wrt your modification:
I change the code to
class B(object): __slots__ = ('_fields') def __init__(self): _fields = set()
The modified class B has a _fields inside __init__(), not self._fields so it's just a local variable in init, and not accessible anywhere else in the class. Change that to:
 class B(object):
    __slots__ = ('_fields')
    def __init__(self):
        self._fields = set()
To correctly initialise _fields, do this:
 class B(object):
     __slots__ = ('_fields')
     def __init__(self, _fields=None):
         if not _fields:
             self._fields = set()
Wrt further experimentation:
In class D, __slots__ is a variable only inside __init()__. It's not the (special) class variable D.__slots__; or even the instance variable self.__slots__. So it has __dict__.
Class A has none, so also has __dict__.
Class C has __slots__ correctly.
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