I want to implement element in-placing edit using 'contenteditable' attribute. Is it possible to go into the edit state with mouse event simulation instead of user click?
function triggerEvent(element, eventType) {
    let rect = element.getBoundingClientRect();
  console.log(rect);
    let event = new MouseEvent(eventType, {
    clientX: rect.left + 20,
    clientY: rect.top + 10,
    view: window,
    buttons: 1,
    bubbles: true,
  });
  element.dispatchEvent(event);
}
document.getElementById('btn').addEventListener('click', (event) => {
    let editArea = document.getElementById('edit-area');
  editArea.setAttribute('contenteditable', true);
  triggerEvent(editArea, 'mousedown');
});
DEMO: https://jsfiddle.net/lfree/vkeq9fza/1/
You just need to focus the div:
let div = document.querySelector('div');
div.focus();
<div contenteditable="true">Div Content</div>
If I understand correctly, all you're trying to do is set focus to the element. Because you've already enabled contenteditable, the following should be adequate:
editArea.setAttribute('contenteditable', true);
editArea.focus(); // Focus on the input which will activate editing
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