I am able to mute the sound going into the microphone, but not the sound coming out of the speakers. To be specific, I'm only trying to mute the Twilio call, not other sounds in the browser, and certainly not system sounds.
Its straightforward using the Javascript 1.4 library, without needing conference calls etc.
https://www.twilio.com/docs/api/client/connection
e.g.
Twilio.Device.activeConnection().mute(true);
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