I have the following data frame:
import pandas as pd
df = pd.DataFrame({'id':['a','b','c','d','e'],
                   'XX_111_S5_R12_001_Mobile_05':[-14,-90,-90,-96,-91],
                   'YY_222_S00_R12_001_1-999_13':[-103,0,-110,-114,-114],
                   'ZZ_111_S00_R12_001_1-999_13':[1,2.3,3,5,6],
})
df.set_index('id',inplace=True)
df
Which looks like this:
Out[6]:
    XX_111_S5_R12_001_Mobile_05  YY_222_S00_R12_001_1-999_13  ZZ_111_S00_R12_001_1-999_13
id
a                           -14                         -103                          1.0
b                           -90                            0                          2.3
c                           -90                         -110                          3.0
d                           -96                         -114                          5.0
e                           -91                         -114                          6.0
What I want to do is to group the column based on the following regex:
\w+_\w+_\w+_\d+_([\w\d-]+)_\d+
So that in the end it's grouped by Mobile, and 1-999.
What's the way to do it. I tried this but fail to group them:
import re
grouped = df.groupby(lambda x: re.search("\w+_\w+_\w+_\d+_([\w\d-]+)_\d+", x).group(), axis=1)
for name, group in grouped:
    print name
    print group
Which prints:
XX_111_S5_R12_001_Mobile_05
YY_222_S00_R12_001_1-999_13
ZZ_111_S00_R12_001_1-999_13
What we want is name prints  to:
Mobile
1-999
1-999
And group prints the corresponding data frame.
You can use .str.extract on the columns in order to extract substrings for your groupby:
# Performing the groupby.
pat = '\w+_\w+_\w+_\d+_([\w\d-]+)_\d+'
grouped = df.groupby(df.columns.str.extract(pat, expand=False), axis=1)
# Showing group information.
for name, group in grouped:
    print name
    print group, '\n'
Which returns the expected groups:
1-999
    YY_222_S00_R12_001_1-999_13  ZZ_111_S00_R12_001_1-999_13
id                                                          
a                          -103                          1.0
b                             0                          2.3
c                          -110                          3.0
d                          -114                          5.0
e                          -114                          6.0 
Mobile
    XX_111_S5_R12_001_Mobile_05
id                             
a                           -14
b                           -90
c                           -90
d                           -96
e                           -91 
                        After grouping, set the index of the new dataframe to [re.findall(r'\w+_\w+_\w+_\d+_([\w\d-]+)_\d+', col)[0] for col in df.columns] (which is ['Mobile', '1-999', '1-999']).
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