I am very new to python, and I want to be able to detect mouse click events across the entire screen.
This question is closest to what I want, however none of the answers are very descriptive.
How can I do this?
you can handle mouse input using the lib PyUserInput (code sample from github) :
from pymouse import PyMouseEvent
def fibo():
    a = 0
    yield a
    b = 1
    yield b
    while True:
        a, b = b, a+b
        yield b
class Clickonacci(PyMouseEvent):
    def __init__(self):
        PyMouseEvent.__init__(self)
        self.fibo = fibo()
    def click(self, x, y, button, press):
        '''Print Fibonacci numbers when the left click is pressed.'''
        if button == 1:
            if press:
                print(self.fibo.next())
        else:  # Exit if any other mouse button used
            self.stop()
C = Clickonacci()
C.run()
otherwise, you can do it with the Xlib lib : Python Xlib catch/send mouseclick
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