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Changing Multiple Array Elements In Python, it is also possible to change multiple elements in an array at once. To do this, you will need to make use of the slice operator and assign the sliced values a new array to replace them.
Modifying existing NumPy Arrays Unlike Python lists, NumPy doesn't have a append(...) function which effectively means that we can't append data or change the size of NumPy Arrays. For changing the size and / or dimension, we need to create new NumPy arrays by applying utility functions on the old array.
In numpy, += is implemented to do in memory changes, while + returns a new array.
Is this what you are after? Just index the element and assign a new value.
A[2,1]=150
A
Out[345]:
array([[ 1, 2, 3, 4],
[ 5, 6, 7, 8],
[ 9, 150, 11, 12],
[13, 14, 15, 16]])
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