The resolution and bit-depth of images greatly affects overall file size. Color images take up more space than monochrome or grayscale images. The image resolution (image dimension in pixels) is also crucial. The higher is image resolution, the more space images will take.
PDF's are measured in inches as stated above, standard is 8.5" x 11" in the USA.
The page sizes are looking different in your PDF because the images were originally set to different DPI (even if images are identical HxW in pixels). The good news is - it's only a display issue - and can be fixed easily.
PDF internally uses the same graphics model as PostScript. PDF is derived from PostScript. Basically,...
PDF also uses the same basic measurement unit as PostScript: 72 points == 1 inch. You may also use fractions of points. This is the device independent way of stating dimensions.
If you ever use pixels, you can do so. If you do, the absolute size of a graphic object on the display or the printed paper then depends on the current resolution of the display or printer. A square of 72px x 72px is 1inch x 1inch at a 72dpi resolution, but it is 0.1inch x 0.1inch at a 720dpi resolution. Therefore using pixels is a device dependent way of stating dimensions.
A4 dimensions are 'width x height = 595 x 842 pt'.
PDF's inherently a print medium, and its internal coordinates work in terms of 'points' (72pts per inch). The PDF rendering software (Acrobat, FoxIt, Ghostscript, etc...) will query the output device for its DPI rating and internally convert all the point-basec coordinates into device-specific pixel sizes when it comes time to render the PDF for display/print.
You can specify sizes in pixels while building a PDF, certainly. But remember that pixel sizes differ. A 300x300 pixel image will be 1" x 1" square on a 300dpi printer, but 3" by 3" on a 100 dpi monitor.
I sometimes edit my files in GIMP, when I want to edit my pictures and such. When I export for PDF it depends on the quality I need.
I just use this chart (for A4):
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