Is it possible to group by two columns? So the cross product is drawn by geom_point() and geom_smooth()?
As example:
frame <- data.frame(  series <- rep(c('a', 'b'), 6),   sample <- rep(c('glass','water', 'metal'), 4),   data <- c(1:12))  ggplot(frame, aes()) # ...   Such that the points 6 and 12 share a group, but not with 3.
Taking the example from this question, using interaction to combine two columns into a new factor:
# Data frame with two continuous variables and two factors  set.seed(0) x <- rep(1:10, 4) y <- c(rep(1:10, 2)+rnorm(20)/5, rep(6:15, 2) + rnorm(20)/5) treatment <- gl(2, 20, 40, labels=letters[1:2]) replicate <- gl(2, 10, 40) d <- data.frame(x=x, y=y, treatment=treatment, replicate=replicate)  ggplot(d, aes(x=x, y=y, colour=treatment, shape = replicate,   group=interaction(treatment, replicate))) +    geom_point() + geom_line()   
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