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The registry redirector intercepts 32-bit and 64-bit registry calls to their respective logical registry views and maps them to the corresponding physical registry location. The redirection process is transparent to the application.
The Wow6432 registry entry indicates that you're running a 64-bit version of Windows. The OS uses this key to present a separate view of HKEY_LOCAL_MACHINE\SOFTWARE for 32-bit applications that run on a 64-bit version of Windows.
The Wow6432Node registry entry indicates that you are running a 64-bit Windows version. The operating system uses this key to display a separate view of HKEY_LOCAL_MACHINE\SOFTWARE for 32-bit applications that run on 64-bit Windows versions.
KEY_WOW64_64KEY on a 64-bit OS means that the registry access, no matter if it's a 32 or 64 bit process, will access the 64 bit registry view. KEY_WOW64_32KEY on a 64-bit OS means that the registry access, no matter if it's a 32 or 64 bit process, will access the 32 bit registry view.
You can use RegistryKey.OpenBaseKey to solve this problem:
var baseReg = RegistryKey.OpenBaseKey(RegistryHive.LocalMachine, RegistryView.Registry64);
var reg = baseReg.CreateSubKey("Software\\Test");
Under WOW64, certain registry keys are redirected (SOFTWARE). When a 32-bit or 64-bit application makes a registry call for a redirected key, the registry redirector intercepts the call and maps it to the key's corresponding physical registry location. For more information, see Registry Redirector.
You can use the RegistryView Enumeration on RegistryKey.OpenBaseKey Method to open the 32-bit view explicitly and access HKLM\Software\ directly.
I don't know how to solve it using a .reg file. But only in a BAT file, as follow:
You must add /reg:64 at the end of the command line.
ex:
REG ADD "HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\Authentication\LogonUI\Background" /v "OEMBackground" /t REG_DWORD /d 0x00000001 /f /reg:64
Source: Wow6432Node and how to Deploy Registry settings to 64 bit systems via Sccm
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