First time debugging from PC to Mobile Phone work fine, when try again get error.
Any solution how fix this when try more debugging.

Add -debugport=54321 to Run->Parameters Parameters. By the way, the "inconsistent certificates" message is because the apk on the device was compiled with a different version of Delphi than the one you are using right now. You will have to uninstall it from the phone first. You can also use -cleaninstall in the Run->Parameters Parameters field.
There is no easy and fast solution.
You may need to:
Sometimes you will be able to debug again after doing only some of the above steps, however often you will need to do all of them.
Since every try takes plenty of time, I found out that complete Windows restart + device restart is the fastest thing to do.
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