Is it possible to use Cython in appengine (with Python 2.7 specifically)? I could see using it when some code is not performing well, and could use a speed boost by having a statically defined type, or loop optimization, etc...
No, this is very clearly not possible. GAE has very strong restrictions on what you can run inside its sandbox, and one of the most definitively spelled-out restrictions is that you cannot run arbitrary C code:
All code for the Python runtime environment must be pure Python, and not include any C extensions or other code that must be compiled.
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